Abstract Background Recently, cancer immunotherapy has become standard for indefinitely baby opi cancer treatment.Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventional cancer treatments.However, existing cancer immunotherapies have limited clinical benefits becaus
Wind turbine blade leading edge erosion (LEE) reduces energy production and increases wind energy operation and maintenance costs.Degradation of the blade coating and ultimately damage to the underlying blade structure are caused by collisions of falling hydrometeors with rotating blades.The selection of optimal methods to mitigate/reduce LEE are w
Angiopoietin-2 (ANG2/ANGPT2) is a context-dependent TIE2 receptor agonist/antagonist and proangiogenic factor.Although ANG2 neutralization improves tumor angiogenesis and growth inhibition by vascular endothelial growth factor (VEGF)-A signaling blockade, the mechanistic underpinnings of such therapeutic benefits remain poorly explored.We employed
We review work on extreme events, their causes and consequences, by a group of European and American researchers involved in a three-year project on these topics.The review covers theoretical aspects of time series analysis and of extreme value theory, as well as of the deterministic modeling of extreme events, via continuous and discrete dynamic m